Scientists Develop New Technique for Precise Manipulation and Detection of Biomolecules
A team of scientists has developed a new technique for manipulating and detecting biomolecules using CRISPR technology. This new technique, called CRISPR-powered optothermal nanotweezers (CRONT), has the potential to revolutionize biomedical research.
CRONT uses light to heat up gold nanoparticles that are attached to DNA strands. This heat causes the nanoparticles to vibrate, which creates a trap that can capture and hold biomolecules. The CRISPR technology is then used to identify the biomolecules that are trapped in the nanotweezers.
This new technique is a significant advance over traditional optical trapping methods, which are limited in their ability to trap and identify biomolecules. CRONT is more precise and can trap a wider range of biomolecules.
CRONT has a number of potential applications in biomedical research, including:
- Single-molecule sequencing: CRONT could be used to sequence DNA molecules one at a time. This would allow scientists to study the genetic makeup of individual cells and tumors.
- Drug discovery: CRONT could be used to identify new drugs by screening for compounds that interact with specific biomolecules.
- Biomedical diagnostics: CRONT could be used to develop new diagnostic tests for diseases such as cancer.
The development of CRONT is a major breakthrough in biomedical research. This new technique has the potential to revolutionize the way scientists study and treat diseases.
- CRISPR-powered optothermal nanotweezers: Diverse bio-nanoparticle manipulation and single nucleotide identification: https://www.nature.com/articles/s41377-023-01326-9